… we explored the benzimidazolo-thiazole core scaffold. The … ring was replaced by smaller
heterocycles. Herein, we describe … We started our optimization program with the replacement of …

… Optimization of the quinazolinone series from which AMG 487 emerged identified a lead …
Similarly, substitution at the C4-position of the azaquinazolinone core also yielded derivatives …

… of the optimized derivative compounds have produced CXCR3 … of two high affinity CXCR3
antagonists were shown, which … nitrogen atoms in the heterocyclic scaffold of the compound …

… of biologically important heterocyclic compounds, herein we … With the optimization of
reaction conditions, further study of … the above-mentioned optimized reaction conditions in good …

… of inhibitors of the CXCR3 receptor, we showed that five–six fused heterocyclic systems, such
… –six fused heterocycles. (23) It was therefore hypothesized that these heterocyclic moieties …

… Nitrogen containing compounds are very important heterocyclic derivatives in the field of …
J et al, Discovery and optimization of a series of quinazolinone-derived antagonists of CXCR3, …

… Using the these starting materials and our optimized conditions (entry 8, Table 1), the scope
of the protocol was assessed. Twenty dihydropyrazinoquinazolinones were prepared with …

… Fused heterocycles with bridgehead nitrogen atoms are important scaffolds commonly used
… for the subsequent optimization study. The results of the optimization study are shown in …

… Herein, we describe the discovery and optimization of a series of propeller shaped PI3Kδ
inhibitors comprising a novel triaminopyrimidine hinge binder. Combinations of electronic and …

… CXCR3 antagonists [5–7]. The conventional methods previously reported for the synthesis
(Gould-Jacob type reaction) [8–10] and the functionalization (Suzuki-Miyaura reaction) [11] of …